Applied R&D Services
Nordion's specialized knowledge in radiopharmaceutical development and manufacturing helps biotechnology and pharmaceutical companies bring new drugs from concept to market reality. We can help at each step of the drug discovery and development process.
This diagram highlights the discovery and pre-clinical services that we offer for radiopharmaceutical development, clinical and commercial manufacturing, and radiation-based medical device development.
- Radioisotope production, supply
- Radiochemistry (chelates, conjugation, iodine)
- Preliminary radiolabeling (125I) to generate and screen leads for RTx
- Postlabeling characterization and analysis
- Biodistribution studies
- Formulation development/optimization
- Radiolabeling lead and back-up (131I, 177Lu
- In vitro potency in tumor cell line
- In vitro efficacy studies in animal tumor models
- Lead development
- Bioanalytical essay development and validation
- Preclinical proof-of-efficacy, tumor localization, dosimetry studies
- GLP safety pharmacology and toxicology (ADMET) studies
|
